PR Newswire
03 Aug 2023, 04:30 GMT+10
SYDNEY, Aug. 3, 2023 /PRNewswire/ -- Arbele, a clinical-stage biotechnology company developing novel immunotherapies targeted for advanced gastrointestinal cancers, presented early safety data from its first-in-class CDH17xCD3 bispecific T-cell engager antibody, ARB202, at the ASCO Breakthrough conference in Yokohama, Japan.
Preliminary data from Phase 1a study indicate ARB202 tolerability up to 150ng/ml Cmax in circulation, suggesting no clinically significant off-target T-cell activation at these levels. A total of ten (10) [6 colorectal carcinoma; 2 cholangiocarcinoma; 1 gastric cancer; 1 gastrointestinal adenocarcinoma] have completed dosing across the first 3 dose-level cohorts ranging from 0.0003 to 0.003 mg/kg by single IV doses. The Cmax measured within 1 hour of dosing confirms the circulating PK range of 10-20 ng/ml for the 2nd cohort and 40-50 ng/ml in the 3rd cohort, which are consistent with the expected PK. As of 29 Jun 2023, the safety review committee and an independent data monitoring committee, DMC, had approved the trial to continue without modification.
These data allow for continued dose escalation with the aim of identifying the optimal dose where ARB202 mediates CDH17-specific immunological synapse formation between target cancer cells and T-cells in solid tumors with minimal on-target effects on normal cells. As these data mature, Arbele intends to present more findings at an appropriate scientific meeting.
"We are excited by the current safety profile of ARB202 and indications of clinical activity. They are consistent with us entering the therapeutic window which is competitive and perhaps even more specific than other T-cell engagers directed at solid tumors." said Dr Dennis Wong, Chief Medical Officer at Arbele.
About ARB202
ARB202 is a first-in-class bispecific antibody based on Arbele's patented CDH17 biomarker. It targets both CDH17 on GI cancer as well as CD3 on T cells. The unique differential binding affinities of ARB202 toward CDH17 and CD3 allows it to have high specificity and cytotoxicity, while avoiding the "off-target" overactivation of T cells. Preclinical data showed that ARB202 can facilitate T-cell activation and release of IL-2, thereby demonstrating target engagement and cytotoxicity. The Phase 1 trial is currently enrolling patients in Australia and Hong Kong (NCT05411133).
About Arbele
Arbele is founded in 2016 by former senior executives from multinational pharmaceutical companies, with R&D presence in Hong Kong, Sydney, Seattle, Guangzhou and Singapore. It focuses on the development of breakthrough diagnostic platforms and innovative immunotherapy; to provide early intervention and treatment for people with gastrointestinal cancers including but not limited to colorectal cancer, pancreatic cancer, gastric cancer, gastroesophageal junction cancer, liver cancer and cholangiocarcinoma, for which effective treatment options are scanty with high mortality rates. For more information on ARBELE, please visit http://www.arbelebio.com/
Media and Investor Contact:
Dr. Diana Hay, PhD
Executive Director, Portfolio and Business Development
[email protected]
Get a daily dose of Malaysia Sun news through our daily email, its complimentary and keeps you fully up to date with world and business news as well.
Publish news of your business, community or sports group, personnel appointments, major event and more by submitting a news release to Malaysia Sun.
More InformationBANGKOK, Thailand: This week, Thailand implemented land border restrictions, including a ban on tourists traveling to Cambodia, as...
(250630) -- VIENTIANE, June 30, 2025 (Xinhua) -- People participate in the Rocket Festival in Vientiane Province, Laos, June 29, 2025....
New Delhi [India], June 30 (ANI): World Super Kabaddi League (WSKL) and the Uttar Pradesh Kabaddi League (UPKL) announced the launch...
New Delhi [India], June 30 (ANI): In a swift and decisive operation, the Indian Navy's stealth frigate INS Tabar responded to a distress...
Mobile payments are dominant in the Asian country, while the traditional means of exchange has dwindled to near extinction, the outlet...
Mobile payments are dominant in the Asian country, while the traditional means of exchange has dwindled to near extinction, the outlet...
WASHINGTON, D.C.: On Friday, President Donald Trump announced that he was halting trade discussions with Canada due to its decision...
LONDON, U.K.: A little-known investment fund based in the United Arab Emirates has emerged as the most prominent public backer of U.S....
SAN FRANCISCO, California: Across the U.S., a growing number of people are taking obesity treatment into their own hands — literally....
SAN FRANCISCO, California: Under pressure from European regulators, Apple has revamped its App Store policies in the EU, introducing...
NEW YORK CITY, New York: The U.S. dollar tumbled this week, hitting its lowest levels since 2021 against the euro, British pound, and...
NEW YORK CITY, New York: Walmart is set to close a major Sam's Club fulfillment center in Fort Worth, Texas, as part of a shift in...